A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - Cancer Research, 2024 - AACR
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - Cancer Research, 2024 - AACR
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

[PDF][PDF] A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - med.upenn.edu
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

[PDF][PDF] A HISTONE METHYLATION-MAPK SIGNALING AXIS DRIVES DURABLE EPITHELIAL-MESENCHYMAL TRANSITION IN HYPOXIC PANCREAS CANCER

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - researchgate.net
(EMT) in pancreatic ductal adenocarcinoma (PDAC) primarily through a positive-feedback
histone methylation-MAPK signaling axis. We find that neoplastic PDAC cells preferentially …

[PDF][PDF] A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - bioethics.upenn.edu
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

[PDF][PDF] A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - depressiongenetics.med.upenn.edu
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreas cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - bioRxiv, 2022 - biorxiv.org
Here, we show that hypoxia drives especially long-lasting epithelial-mesenchymal transition
(EMT) in pancreatic ductal adenocarcinoma (PDAC) primarily through a positive-feedback …

[PDF][PDF] A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - depressiongenetics.med.upenn.edu
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - Cancer …, 2024 - pubmed.ncbi.nlm.nih.gov
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …

A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer.

BA Brown, PJ Myers, SJ Adair, JR Pitarresi… - Cancer …, 2024 - europepmc.org
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role
in tumor progression and response to therapy. The dense PDAC stroma causes …