[HTML][HTML] Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

G Aljayyoussi, VA Jenkins, R Sharma, A Ardrey… - Scientific reports, 2017 - nature.com
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs
taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently …

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

G Aljayyoussi, VA Jenkins, R Sharma, A Ardrey… - scienceopen.com
Simulations of time kill dynamics of (a) RIF,(b) ETB,(c) INH, and (d) PZA. The simulations are
based on the final model parameters and overlaid with data±SD for selected concentrations …

[PDF][PDF] Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosisgrowth and kill rates is predictive of clinical treatment

G Aljayyoussi, VA Jenkins, R Sharma, A Ardrey… - core.ac.uk
Results Growth rate of Mtb within macrophages is significantly reduced compared to
planktonic Mtb grown in liquid culture. The described optimized high-content imaging …

[PDF][PDF] Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosisgrowth and kill rates is predictive of clinical treatment

G Aljayyoussi, VA Jenkins, R Sharma, A Ardrey… - napier.ac.uk
Results Growth rate of Mtb within macrophages is significantly reduced compared to
planktonic Mtb grown in liquid culture. The described optimized high-content imaging …

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

G Aljayyoussi, VA Jenkins, R Sharma… - Scientific …, 2017 - ui.adsabs.harvard.edu
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs
taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently …

[PDF][PDF] Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosisgrowth and kill rates is predictive of clinical treatment

G Aljayyoussi, VA Jenkins, R Sharma, A Ardrey… - researchgate.net
Results Growth rate of Mtb within macrophages is significantly reduced compared to
planktonic Mtb grown in liquid culture. The described optimized high-content imaging …

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.

G Aljayyoussi, VA Jenkins, RS Raman Sharma… - 2017 - cabidigitallibrary.org
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs
taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently …

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.

G Aljayyoussi, VA Jenkins, R Sharma, A Ardrey… - Scientific …, 2017 - europepmc.org
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs
taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently …

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

G Aljayyoussi, VA Jenkins, R Sharma… - Scientific …, 2017 - pubmed.ncbi.nlm.nih.gov
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs
taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently …

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

G Aljayyoussi, V Jenkins, R Sharma… - Scientific …, 2017 - archive.lstmed.ac.uk
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs
taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently …