Metal ion interactions with mAbs: Part 1: pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region

ZK Glover, L Basa, B Moore, JS Laurence, A Sreedhara - MAbs, 2015 - Taylor & Francis
Fragmentation in the hinge region of an IgG1 monoclonal antibody (mAb) can affect product
stability, potentially causing changes in potency and efficacy. Metals ions, such as Cu2+ …

[引用][C] Metal ion interactions with mAbs: Part 1

ZK Glover, L Basa, B Moore, JS Laurence, A Sreedhara - mAbs, 2015 - cir.nii.ac.jp
Metal ion interactions with mAbs: Part 1 | CiNii Research CiNii 国立情報学研究所 学術情報
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[HTML][HTML] Metal ion interactions with mAbs: Part 1: pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region

ZK Glover, L Basa, B Moore, JS Laurence, A Sreedhara - mAbs, 2015 - ncbi.nlm.nih.gov
Fragmentation in the hinge region of an IgG1 monoclonal antibody (mAb) can affect product
stability, potentially causing changes in potency and efficacy. Metals ions, such as Cu 2+ …

Metal ion interactions with mAbs: Part 1

ZK Glover, L Basa, B Moore, JS Laurence… - …, 2015 - pubmed.ncbi.nlm.nih.gov
Fragmentation in the hinge region of an IgG1 monoclonal antibody (mAb) can affect product
stability, potentially causing changes in potency and efficacy. Metals ions, such as Cu (2+) …

Metal ion interactions with mAbs: Part 1.

ZK Glover, L Basa, B Moore, JS Laurence, A Sreedhara - Mabs, 2015 - europepmc.org
Fragmentation in the hinge region of an IgG1 monoclonal antibody (mAb) can affect product
stability, potentially causing changes in potency and efficacy. Metals ions, such as Cu 2+ …

Metal ion interactions with mAbs: Part 1.

ZK Glover, L Basa, B Moore, JS Laurence, A Sreedhara - Mabs, 2015 - europepmc.org
Fragmentation in the hinge region of an IgG1 monoclonal antibody (mAb) can affect product
stability, potentially causing changes in potency and efficacy. Metals ions, such as Cu 2+ …