Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting “block and lock” treatment strategies

RM Horvath, ZL Brumme… - Antimicrobial Agents and …, 2024 - Am Soc Microbiol
Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The “block and lock” …
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[HTML][HTML] Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting “block and lock” treatment strategies

RM Horvath, ZL Brumme, I Sadowski - Antimicrobial Agents and …, 2024 - ncbi.nlm.nih.gov
Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The “block and lock” …

Small molecule inhibitors of transcriptional Cyclin Dependent Kinases impose HIV-1 latency, presenting “block and lock” treatment strategies

RM Horvath, ZL Brumme, I Sadowski - bioRxiv, 2023 - biorxiv.org
Antiretroviral therapy is not a cure for HIV-1 infection, as viral rebound inevitably occurs
following discontinuation of treatment. The “block and lock” therapeutic strategy seeks to …

Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting" block and lock" treatment strategies.

RM Horvath, ZL Brumme, I Sadowski - Antimicrobial Agents and …, 2024 - europepmc.org
Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The" block and lock" …

Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting" block and lock" treatment strategies

RM Horvath, ZL Brumme… - Antimicrobial agents …, 2024 - pubmed.ncbi.nlm.nih.gov
Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The" block and lock" …

[引用][C] Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting “block and lock” treatment strategies

RM Horvath, ZL Brumme, I Sadowski - 2024 - europepmc.org
Current antiretroviral therapy for HIV-1 infection does not represent a cure for infection as
viral rebound inevitably occurs following discontinuation of treatment. The “block and lock” …