In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

WH Yeh, O Shubina-Oleinik, JM Levy, B Pan… - Science translational …, 2020 - science.org
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …

[引用][C] In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

WH Yeh, O Shubina-Oleinik, JM Levy, B Pan… - Science Translational …, 2020 - cir.nii.ac.jp
In vivo base editing restores sensory transduction and transiently improves auditory function in
a mouse model of recessive deafness | CiNii Research CiNii 国立情報学研究所 学術情報 …

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

WH Yeh, O Shubina-Oleinik… - Science …, 2020 - pubmed.ncbi.nlm.nih.gov
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.

WH Yeh, O Shubina-Oleinik, JM Levy… - Science Translational …, 2020 - europepmc.org
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …

[HTML][HTML] In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

WH Yeh, O Shubina-Oleinik, JM Levy… - Science translational …, 2020 - ncbi.nlm.nih.gov
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.

WH Yeh, O Shubina-Oleinik, JM Levy… - Science …, 2020 - search.ebscohost.com
At the base of deafness: Mutations in the transmembrane channel-like 1 (TMC1) gene can
cause hereditary hearing loss. Current treatments do not target the cause of the disease …

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

WH Yeh, O Shubina-Oleinik, J Levy, B Pan… - Sci. Transl …, 2020 - dash.harvard.edu
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

WH Yeh, O Shubina-Oleinik, JM Levy… - Science …, 2020 - pure.johnshopkins.edu
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …