[HTML][HTML] Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim, P Zhang… - Nature …, 2020 - nature.com
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim… - Nature …, 2020 - ui.adsabs.harvard.edu
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

[HTML][HTML] Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim, P Zhang… - Nature …, 2020 - ncbi.nlm.nih.gov
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.

Y He, X Zhang, J Chang, HN Kim, P Zhang… - Nature …, 2020 - escholarship.org
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

[PDF][PDF] Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and

Y He, X Zhang, J Chang - Nature communications, 2020 - scholar.archive.org
Results PZ selectively kills SCs with reduced platelet toxicity. By analyzing previously
published human platelet RNA sequencing data, we found that the CRBN E3 ligase and its …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.

Y He, X Zhang, J Chang, HN Kim, P Zhang… - Nature …, 2020 - europepmc.org
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim… - Nature …, 2020 - pubmed.ncbi.nlm.nih.gov
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim… - Nature …, 2020 - econpapers.repec.org
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim, P Zhang… - Nature …, 2020 - cir.nii.ac.jp
抄録< jats: title> Abstract</jats: title>< jats: p> Small molecules that selectively kill senescent
cells (SCs), termed senolytics, have the potential to prevent and treat various age-related …

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Y He, X Zhang, J Chang, HN Kim… - Nature …, 2020 - pure.johnshopkins.edu
Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …