A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

RJ Carlson, MD Leiken, A Guna… - Proceedings of the …, 2023 - National Acad Sciences
The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

RJ Carlson, MD Leiken, A Guna… - Proceedings of the …, 2023 - ui.adsabs.harvard.edu
Our study demonstrates scaling of optical pooled screening to the genome-wide level.
Profile-based screening is a uniquely powerful phenotype-based genetic tool that enables …

[HTML][HTML] A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

RJ Carlson, MD Leiken, A Guna… - Proceedings of the …, 2023 - ncbi.nlm.nih.gov
Results A Genome-Wide Optical Pooled Screen Identifies Regulators of IRF3 Translocation.
We performed a genome-wide optical pooled screen using a lentivirus library of 80,408 …

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.

RJ Carlson, MD Leiken, A Guna… - Proceedings of the …, 2023 - europepmc.org
Results A Genome-Wide Optical Pooled Screen Identifies Regulators of IRF3 Translocation.
We performed a genome-wide optical pooled screen using a lentivirus library of 80,408 …

[PDF][PDF] A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

RJ Carlsona, MD Leikenb, A Guna, N Hacohenb… - 2023 - hacohenlab.mgh.harvard.edu
Results A Genome-Wide Optical Pooled Screen Identifies Regulators of IRF3 Translocation.
We performed a genome-wide optical pooled screen using a lentivirus library of 80,408 …

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

RJ Carlson, MD Leiken, A Guna… - Proceedings of the …, 2023 - pubmed.ncbi.nlm.nih.gov
The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

[PDF][PDF] A Genome-Wide Optical Pooled Screen Reveals Regulators of Cellular Antiviral Responses

BIE Salon, L Avey, S Jobs - scienceinboston.com
The authors carry out a genome-wide CRISPR knockout screen using highresolution
multiparameter imaging of cellular responses to Sendai virus infection coupled with in situ …

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.

RJ Carlson, MD Leiken, A Guna… - Proceedings of the …, 2023 - europepmc.org
The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

[PDF][PDF] A Genome-Wide Optical Pooled Screen Reveals Regulators of Cellular Antiviral Responses

BIE Salon, L Avey, S Jobs - scienceinboston.com
The authors carry out a genome-wide CRISPR knockout screen using highresolution
multiparameter imaging of cellular responses to Sendai virus infection coupled with in situ …