Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome

RJ Wiener, H Orins, KD Costa - bioRxiv, 2023 - biorxiv.org
Marfan Syndrome (MFS), a connective tissue disorder caused by a mutation in the fibrillin-1
gene, occurs in approximately 1 in 5,000 people worldwide. As an important constituent of …

Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome

RJ Wiener, KD Costa - 2023 - europepmc.org
Marfan Syndrome (MFS), a connective tissue disorder caused by a mutation in the fibrillin-1
gene, occurs in approximately 1 in 5,000 people worldwide. As an important constituent of …