Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

S Guo, S Zhang, Y Zhuang, F Xie… - Proceedings of the …, 2023 - National Acad Sciences
Poly (ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

S Guo, S Zhang, Y Zhuang, F Xie… - Proceedings of the …, 2023 - ui.adsabs.harvard.edu
The activity of PARP1 was increased in the skeletal muscle of aged humans, mice, and
Drosophila. The knockdown of PARP1, specifically in muscle, extended the lifespan of …

[PDF][PDF] Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

S Guoa, S Zhangb, Y Zhuanga, F Xiea, R Wangb… - 2023 - pdfs.semanticscholar.org
Species during Aging. To investigate the relationship between PARP1 and aging, we initially
assessed the expression and activity of PARP1 in the skeletal muscle of different species …

[HTML][HTML] Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

S Guo, S Zhang, Y Zhuang, F Xie, R Wang… - Proceedings of the …, 2023 - ncbi.nlm.nih.gov
Species during Aging. To investigate the relationship between PARP1 and aging, we initially
assessed the expression and activity of PARP1 in the skeletal muscle of different species …

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.

S Guo, S Zhang, Y Zhuang, F Xie, R Wang… - Proceedings of the …, 2023 - europepmc.org
Poly (ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

S Guo, S Zhang, Y Zhuang, F Xie… - Proceedings of the …, 2023 - pubmed.ncbi.nlm.nih.gov
Poly (ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in
longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of …

[引用][C] Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

S Guoa, S Zhangb, Y Zhuanga, F Xiea, R Wangb… - 2023 - europepmc.org
Species during Aging. To investigate the relationship between PARP1 and aging, we initially
assessed the expression and activity of PARP1 in the skeletal muscle of different species …