Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis

Z Cao, Y Liu, S Chen, W Wang, Z Yang, Y Chen… - Biochemical …, 2023 - Elsevier
Abstract Human carboxylesterase 2 (hCES2) is an enzyme that metabolizes irinotecan to SN-
38, a toxic metabolite considered a significant source of side effects (lethal delayed …
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Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis

Z Cao, Y Liu, S Chen, W Wang… - Biochemical …, 2023 - pubmed.ncbi.nlm.nih.gov
Human carboxylesterase 2 (hCES2) is an enzyme that metabolizes irinotecan to SN-38, a
toxic metabolite considered a significant source of side effects (lethal delayed diarrhea). The …

Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis.

Z Cao, Y Liu, S Chen, W Wang, Z Yang… - Biochemical …, 2023 - europepmc.org
Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and
ulcerative colitis. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe …