Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - National Acad Sciences
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-
antigens have employed altered peptide antigens to activate T cell responses capable of …

Breaking Tolerance with Engineered Class I Antigen Presenting Molecules

CA Parks - 2018 - search.proquest.com
The cornerstone of the properly functioning immune system is the recognition and
elimination of that which is foreign and the preservation of that which is self. The ability of the …

Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning… - … of the National …, 2019 - mayoclinic.elsevierpure.com
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-
antigens have employed altered peptide antigens to activate T cell responses capable of …

[HTML][HTML] Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - ncbi.nlm.nih.gov
Results Single Amino Acid Substitutions of H-2Kb Heavy Chain Designed to Enhance TCR
Binding but Not Peptide Binding. A combination of structural analysis and molecular …

Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - experts.illinois.edu
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-
antigens have employed altered peptide antigens to activate T cell responses capable of …

Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning, KD Pavelko, MJ Hansen… - Proceedings of the …, 2019 - JSTOR
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-
antigens have employed altered peptide antigens to activate T cell responses capable of …

Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - ui.adsabs.harvard.edu
Provision of sufficient activating signals can drive self-tolerant T cells to cross-react on self-
peptide-MHC in a breakdown of tolerance. This approach has been applied in the …

Breaking tolerance with engineered class I antigen-presenting molecules

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - pubmed.ncbi.nlm.nih.gov
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-
antigens have employed altered peptide antigens to activate T cell responses capable of …

Breaking tolerance with engineered class I antigen-presenting molecules.

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - europepmc.org
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-
antigens have employed altered peptide antigens to activate T cell responses capable of …

Breaking tolerance with engineered class I antigen-presenting molecules.

CA Parks, KR Henning, KD Pavelko… - Proceedings of the …, 2019 - europepmc.org
Results Single Amino Acid Substitutions of H-2Kb Heavy Chain Designed to Enhance TCR
Binding but Not Peptide Binding. A combination of structural analysis and molecular …