Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …

Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …

Sen1 is an essential helicase for factor-dependent transcription termination in
Saccharomyces cerevisiae, whose molecular-motor mechanism has not been well …

In the yeast Saccharomyces cerevisiae, the essential nuclear helicase Sen1 is required for
efficient termination of transcription of short noncoding RNA genes by RNA polymerase II …

Abstract The superfamily 1B (SF 1B) helicase Sen1 is an essential protein that plays a key
role in the termination of noncoding transcription in yeast. Here, we identified the~ 90 kDa …

Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of noncoding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …

Extrinsic transcription termination typically involves remodeling of RNA polymerase by an
accessory helicase. In yeast this is accomplished by the Sen1 helicase homologous to …

Factor-dependent termination uses molecular motors to remodel transcription machineries,
but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we …

Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription
termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II …

The essential helicase-like protein Sen1 mediates termination of RNA Polymerase II (Pol II)
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II …