BACKGROUND: Cumulative adversity and stress are associated with risk of psychiatric
disorders. While basic science studies show repeated and chronic stress effects on …

Background Studies of psychiatric populations have reported associations between
childhood adversity and volumes of stress-related brain structures. This meta-analysis …

Childhood adversity plays an important role for development of major depressive disorder
(MDD). There are differences in subcortical brain structures between patients with MDD and …

Cumulative adversity (CA) increases stress sensitivity and risk of adverse health outcomes.
However, neural mechanisms underlying these associations in humans remain unclear. To …

Although stressful life events (SLEs) have been associated with an increased risk of illness
and mental disorder, their impact on brain anatomy remains poorly understood. Using a …

Background We examined the neurobiological mechanisms underlying stress susceptibility
using structural magnetic resonance imaging and diffusion tensor imaging to determine …

Chronic stress in non-human animals decreases the volume of the hippocampus, a brain
region that supports learning and memory and that regulates neuroendocrine activity. In …

Different dimensions of adversity may affect mental health through distinct neurobiological
mechanisms, though current supporting evidence consists largely of cross-sectional …

Exploration of the relationships between regional brain volume and anxiety-related
personality traits is important for understanding preexisting vulnerability to depressive and …

BACKGROUND: The hopelessness theory of depression posits that individuals with
negative cognitive styles are at an increased risk for depression following negative life …