It has been 30 years since a'new'leukaemia termed adult T-cell leukaemia (ATL) was
described in Japan, and more than 25 years since the isolation of the retrovirus, human T …

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be
causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has …

I briefly review the discovery and characterization of the first human retrovirus, human T-cell
leukemia virus type 1, focusing on contributions from Japanese researchers. The unique …

Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in about 5%
of carriers after a long latent period. After its infection, HTLV-I promotes the clonal …

Human T cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in 2–5% of
carriers after a long latent period. An HTLV-I encoded protein, Tax, induces proliferation and …

Highlights•HTLV-1 primarily transmits by cell-to-cell contact.•HTLV-1 increases the number
of infected cells by clonal proliferation to facilitate its transmission.•HTLV-1 bZIP factor (HBZ) …

Adult T-cell leukemia (ATL) was first described in 1977. A link between ATL and human T-
cell leukemia virus type 1 (HTLV-1) was clearly established in the early 1980s. Over the …

Human T-cell leukemia virus type I (HTLV-I) 1 causes adult T-cell leukemia (ATL)(1–3). The
virus is also associated with a neuropathy/myelopathy termed HTLV-associated myelopathy …

The mechanism of human T-cell leukemia virus (HTLV)-mediated transformation and
induction of malignancy is unknown; however, several studies have implicated the viral …

Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infects 15-20 millions individuals
worldwide. This oncoretrovirus can be transmitted through 3 ways: horizontally, vertically …