The study of nicotinic acetylcholine receptors (nAChRs) has significantly progressed in the
last decade, due to a) the improved techniques available for structural studies; b) the …

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important
targets for drug discovery. The therapeutic potential of nicotinic agonists depends …

Discovery of the important role played by nicotinic acetylcholine receptors (nAChRs) in
several CNS disorders has called attention to these membrane proteins and to ligands able …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand gated ion channels, which
are found at the neuromuscular junction and in the central and peripheral nervous systems …

For decades, the development of selective compounds has been the main goal for chemists
and biologists involved in drug discovery. However, diverse lines of evidence indicate that …

Introduction: Nicotinic acetylcholine receptors (nAChRs), pentameric ligand-gated cation
channels, are potential targets for the development of therapeutics for a variety of disease …

Publisher Summary The pharmacology of nicotinic acetylcholine receptors (nAChRs) has
been intensively researched. The current interest in the medicinal chemistry aspects of …

In contrast to the considerable effort over many years to design agonists of the muscarinic
acetylcholine receptor, until recently little attention has been directed towards agonists of the …

Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …