Exposure to the Natural Compound Climacostol Induces Cell Damage and Oxidative Stress in the Fruit Fly Drosophila melanogaster

E Catalani, K Brunetti, S Del Quondam, S Bongiorni… - Toxics, 2024 - mdpi.com
The ciliate Climacostomum virens produces the metabolite climacostol that displays
antimicrobial activity and cytotoxicity on human and rodent tumor cells. Given its potential as …

Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme

C Perrotta, F Buonanno, S Zecchini, A Giavazzi… - Scientific reports, 2016 - nature.com
Climacostol, a compound produced by the ciliated protozoan Climacostomum virens,
displayed cytotoxic properties in vitro. This study demonstrates that it has anti-tumour …

Natural function and structural modification of climacostol, a ciliate secondary metabolite

F Buonanno, E Catalani, D Cervia, C Cimarelli… - Microorganisms, 2020 - mdpi.com
The review highlights the main results of two decades of research on climacostol (5-[(2 Z)-
non-2-en-1-yl] benzene-1, 3-diol), the resorcinolic lipid produced and used by the ciliated …

DNA binding and oxidative DNA damage induced by climacostol–copper (II) complexes: Implications for anticancer properties

L Quassinti, F Ortenzi, E Marcantoni… - Chemico-biological …, 2013 - Elsevier
Climacostol is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum
virens and belongs to the group of resorcinolic lipids. Climacostol exerts a potent …

The natural compound climacostol as a prodrug strategy based on pH activation for efficient delivery of cytotoxic small agents

E Catalani, F Buonanno, G Lupidi, S Bongiorni… - Frontiers in …, 2019 - frontiersin.org
We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic
natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis …

Climacostol inhibits Tetrahymena motility and mitochondrial respiration

Y Muto, Y Tanabe, K Kawai, Y Okano, H Iio - Open Life Sciences, 2011 - degruyter.com
Climacostol is a resorcinol derivative that is produced by the ciliate Climacostomum virens.
Exposure to purified climacostol results in lethal damage to the predatory ciliate Dileptus …

Bioactivity and structural properties of novel synthetic analogues of the protozoan toxin climacostol

F Buonanno, E Catalani, D Cervia, F Proietti Serafini… - Toxins, 2019 - mdpi.com
Climacostol (5-[(2 Z)-non-2-en-1-yl] benzene-1, 3-diol) is a resorcinol produced by the
protozoan Climacostomum virens for defence against predators. It exerts a potent …

The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines

F Buonanno, L Quassinti, M Bramucci… - Chemico-biological …, 2008 - Elsevier
Climacostol (5-(Z)-non-2-enyl-benzene-1, 3-diol) is a natural toxin isolated from the
freshwater ciliated protozoan Climacostomum virens and belongs to the group of …

Chronic sub-lethal exposure to clothianidin triggers organismal and sub-organismal-level health hazards in a non-target organism, Drosophila melanogaster

S Nanda, A Ganguly, M Mandi, K Das, S Ghanty… - Science of The Total …, 2024 - Elsevier
Neonicotinoids are among the most widely used systemic pesticides across the world.
These chemicals have gathered significant attention for their potential adverse impacts on …

Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster

MAI Ahmed, CFA Vogel - Chemosphere, 2020 - Elsevier
Recent reports demonstrate that octopamine receptor (OR) agonists such as formamidine
pesticides cause reproductive and developmental toxicity through endocrine disrupting …