Exposure to the Natural Compound Climacostol Induces Cell Damage and Oxidative Stress in the Fruit Fly Drosophila melanogaster
E Catalani, K Brunetti, S Del Quondam, S Bongiorni… - Toxics, 2024 - mdpi.com
The ciliate Climacostomum virens produces the metabolite climacostol that displays
antimicrobial activity and cytotoxicity on human and rodent tumor cells. Given its potential as …
antimicrobial activity and cytotoxicity on human and rodent tumor cells. Given its potential as …
Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme
C Perrotta, F Buonanno, S Zecchini, A Giavazzi… - Scientific reports, 2016 - nature.com
Climacostol, a compound produced by the ciliated protozoan Climacostomum virens,
displayed cytotoxic properties in vitro. This study demonstrates that it has anti-tumour …
displayed cytotoxic properties in vitro. This study demonstrates that it has anti-tumour …
Natural function and structural modification of climacostol, a ciliate secondary metabolite
The review highlights the main results of two decades of research on climacostol (5-[(2 Z)-
non-2-en-1-yl] benzene-1, 3-diol), the resorcinolic lipid produced and used by the ciliated …
non-2-en-1-yl] benzene-1, 3-diol), the resorcinolic lipid produced and used by the ciliated …
DNA binding and oxidative DNA damage induced by climacostol–copper (II) complexes: Implications for anticancer properties
L Quassinti, F Ortenzi, E Marcantoni… - Chemico-biological …, 2013 - Elsevier
Climacostol is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum
virens and belongs to the group of resorcinolic lipids. Climacostol exerts a potent …
virens and belongs to the group of resorcinolic lipids. Climacostol exerts a potent …
The natural compound climacostol as a prodrug strategy based on pH activation for efficient delivery of cytotoxic small agents
E Catalani, F Buonanno, G Lupidi, S Bongiorni… - Frontiers in …, 2019 - frontiersin.org
We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic
natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis …
natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis …
Climacostol inhibits Tetrahymena motility and mitochondrial respiration
Y Muto, Y Tanabe, K Kawai, Y Okano, H Iio - Open Life Sciences, 2011 - degruyter.com
Climacostol is a resorcinol derivative that is produced by the ciliate Climacostomum virens.
Exposure to purified climacostol results in lethal damage to the predatory ciliate Dileptus …
Exposure to purified climacostol results in lethal damage to the predatory ciliate Dileptus …
Bioactivity and structural properties of novel synthetic analogues of the protozoan toxin climacostol
Climacostol (5-[(2 Z)-non-2-en-1-yl] benzene-1, 3-diol) is a resorcinol produced by the
protozoan Climacostomum virens for defence against predators. It exerts a potent …
protozoan Climacostomum virens for defence against predators. It exerts a potent …
The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines
F Buonanno, L Quassinti, M Bramucci… - Chemico-biological …, 2008 - Elsevier
Climacostol (5-(Z)-non-2-enyl-benzene-1, 3-diol) is a natural toxin isolated from the
freshwater ciliated protozoan Climacostomum virens and belongs to the group of …
freshwater ciliated protozoan Climacostomum virens and belongs to the group of …
Chronic sub-lethal exposure to clothianidin triggers organismal and sub-organismal-level health hazards in a non-target organism, Drosophila melanogaster
S Nanda, A Ganguly, M Mandi, K Das, S Ghanty… - Science of The Total …, 2024 - Elsevier
Neonicotinoids are among the most widely used systemic pesticides across the world.
These chemicals have gathered significant attention for their potential adverse impacts on …
These chemicals have gathered significant attention for their potential adverse impacts on …
Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster
Recent reports demonstrate that octopamine receptor (OR) agonists such as formamidine
pesticides cause reproductive and developmental toxicity through endocrine disrupting …
pesticides cause reproductive and developmental toxicity through endocrine disrupting …
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