Background Obesity is a major health problem that is determined by interactions between
lifestyle and environmental and genetic factors. Although associations between several …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …

Background DNA methylation is associated with body mass index (BMI), but it is not clear if
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …

Results: Cross-sectional analysis identified 310 CpGs associated with BMI with P< 1.0× 10−
7, 225 of which had not been reported previously. Of these 225 novel associations, 172 …

Background DNA methylation has been shown to be associated with adiposity in adulthood.
However, whether similar DNA methylation patterns are associated with childhood and …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Multiple differentially methylated sites and regions associated with adiposity have now been
identified in large-scale cross-sectional studies. We tested for replication of associations …

Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …