Candidate genes for cannabis use disorders: findings, challenges and directions

A Agrawal, MT Lynskey - Addiction, 2009 - Wiley Online Library
Aim Twin studies have shown that cannabis use disorders (abuse/dependence) are highly
heritable. This review aims to:(i) review existing linkage studies of cannabis use disorders …

An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project

A Agrawal, ML Pergadia, SF Saccone… - Archives of General …, 2008 - jamanetwork.com
Context Despite accumulating evidence that there is a genetic basis for cannabis use
disorders (ie, abuse and dependence), few studies have identified genomic regions that …

Genome-wide association study identifies a novel locus for cannabis dependence

A Agrawal, YL Chou, CE Carey, DAA Baranger… - Molecular …, 2018 - nature.com
Despite moderate heritability, only one study has identified genome-wide significant loci for
cannabis-related phenotypes. We conducted meta-analyses of genome-wide association …

Cannabis controversies: how genetics can inform the study of comorbidity

A Agrawal, MT Lynskey - Addiction, 2014 - Wiley Online Library
Aims To review three key and controversial comorbidities of cannabis use—other illicit drug
use, psychosis and depression, as well as suicide, from a genetically informed perspective …

Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans

S Han, BZ Yang, HR Kranzler, D Oslin, R Anton… - Biological …, 2012 - Elsevier
BACKGROUND: A genetic contribution to cannabis dependence (CaD) has been
established but susceptibility genes for CaD remain largely unknown. METHODS: We …

Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans

WE Melroy-Greif, KC Wilhelmsen, CL Ehlers - Drug and alcohol …, 2016 - Elsevier
Background Cannabis is a commonly used drug and studies have shown that a significant
portion of the variation in cannabis use disorders (CUDs) is heritable. Five genes known to …

No association of candidate genes with cannabis use in a large sample of Australian twin families

KJH Verweij, BP Zietsch, JZ Liu, SE Medland… - Addiction …, 2012 - Wiley Online Library
While there is solid evidence that cannabis use is heritable, attempts to identify genetic
influences at the molecular level have yielded mixed results. Here, a large twin family …

Genetic basis of cannabis use: a systematic review

A Hillmer, C Chawar, S Sanger, A D'Elia, M Butt… - BMC Medical …, 2021 - Springer
Background With the increase in cannabis use rates, cannabis use disorder is being
reported as one of the most common drug use disorders globally. Cannabis use has several …

A genomewide association study of DSMIV cannabis dependence

A Agrawal, MT Lynskey, A Hinrichs, R Grucza… - Addiction …, 2011 - Wiley Online Library
Despite twin studies showing that 50–70% of variation in DSMIV cannabis dependence is
attributable to heritable influences, little is known of specific genotypes that influence …

The genetic epidemiology of cannabis use, abuse and dependence

A Agrawal, MT Lynskey - Addiction, 2006 - Wiley Online Library
Aims The genetic etiology of cannabis use, abuse and dependence has elicited significant
interest from genetic epidemiologists. Methods Genetically informative studies, including …