Candidate genes for cannabis use disorders: findings, challenges and directions
A Agrawal, MT Lynskey - Addiction, 2009 - Wiley Online Library
Aim Twin studies have shown that cannabis use disorders (abuse/dependence) are highly
heritable. This review aims to:(i) review existing linkage studies of cannabis use disorders …
heritable. This review aims to:(i) review existing linkage studies of cannabis use disorders …
An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
A Agrawal, ML Pergadia, SF Saccone… - Archives of General …, 2008 - jamanetwork.com
Context Despite accumulating evidence that there is a genetic basis for cannabis use
disorders (ie, abuse and dependence), few studies have identified genomic regions that …
disorders (ie, abuse and dependence), few studies have identified genomic regions that …
Genome-wide association study identifies a novel locus for cannabis dependence
Despite moderate heritability, only one study has identified genome-wide significant loci for
cannabis-related phenotypes. We conducted meta-analyses of genome-wide association …
cannabis-related phenotypes. We conducted meta-analyses of genome-wide association …
Cannabis controversies: how genetics can inform the study of comorbidity
A Agrawal, MT Lynskey - Addiction, 2014 - Wiley Online Library
Aims To review three key and controversial comorbidities of cannabis use—other illicit drug
use, psychosis and depression, as well as suicide, from a genetically informed perspective …
use, psychosis and depression, as well as suicide, from a genetically informed perspective …
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans
BACKGROUND: A genetic contribution to cannabis dependence (CaD) has been
established but susceptibility genes for CaD remain largely unknown. METHODS: We …
established but susceptibility genes for CaD remain largely unknown. METHODS: We …
Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans
WE Melroy-Greif, KC Wilhelmsen, CL Ehlers - Drug and alcohol …, 2016 - Elsevier
Background Cannabis is a commonly used drug and studies have shown that a significant
portion of the variation in cannabis use disorders (CUDs) is heritable. Five genes known to …
portion of the variation in cannabis use disorders (CUDs) is heritable. Five genes known to …
No association of candidate genes with cannabis use in a large sample of Australian twin families
While there is solid evidence that cannabis use is heritable, attempts to identify genetic
influences at the molecular level have yielded mixed results. Here, a large twin family …
influences at the molecular level have yielded mixed results. Here, a large twin family …
Genetic basis of cannabis use: a systematic review
A Hillmer, C Chawar, S Sanger, A D'Elia, M Butt… - BMC Medical …, 2021 - Springer
Background With the increase in cannabis use rates, cannabis use disorder is being
reported as one of the most common drug use disorders globally. Cannabis use has several …
reported as one of the most common drug use disorders globally. Cannabis use has several …
A genomewide association study of DSMIV cannabis dependence
Despite twin studies showing that 50–70% of variation in DSMIV cannabis dependence is
attributable to heritable influences, little is known of specific genotypes that influence …
attributable to heritable influences, little is known of specific genotypes that influence …
The genetic epidemiology of cannabis use, abuse and dependence
A Agrawal, MT Lynskey - Addiction, 2006 - Wiley Online Library
Aims The genetic etiology of cannabis use, abuse and dependence has elicited significant
interest from genetic epidemiologists. Methods Genetically informative studies, including …
interest from genetic epidemiologists. Methods Genetically informative studies, including …