One of the immediate sequelae of bone fracture is regional hypoxia resulting from
vasculature disruption. Hypoxia stabilizes and activates the transcription factor hypoxia …

HIF1α activates genes under hypoxia and was hypothesized to regulate bone
regeneration. Surprisingly, HIF1α+/− fracture calluses are larger, stronger, and stiffer than …

Hypoxiainducible factors (HIFs) are core regulators of the hypoxia response. HIF signaling
is activated in the local physiological and pathological hypoxic environment, acting on …

The hypoxiainducible factors have recently been identified as critical regulators of
angiogenic–osteogenic coupling. Mice overexpressing HIFα subunits in osteoblasts …

The hypoxia-inducible factor-1α (HIF-1α) pathway is the central regulator of adaptive
responses to low oxygen availability and is required for normal skeletal development. Here …

Osteogenesis and angiogenesis are tightly coupled during bone formation and repair. Blood
vessels not only carry oxygen and nutrients to the developing bone, but also play an active …

Objectives: Hypoxiainducible factor 1α (HIF1α) is a pivotal regulator of hypoxic and
ischaemic vascular responses that drives transcriptional activation of hundreds of genes …

Following injury, vascular damage results in the loss of perfusion and consequent low
oxygen tension (hypoxia) which may be exacerbated by a rapid influx of inflammatory and …

Sufficient oxygen is required to maintain normal cellular and physiological function, such as
a creature's development, breeding, and homeostasis. Lately, some researchers have …

Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell
survival. Hypoxia-inducible transcription factors HIF-1 and HIF-2 are central mediators of the …