Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits
While large-scale, genome-wide association studies (GWAS) have identified hundreds of
loci associated with brain-related traits, identification of the variants, genes and molecular …
loci associated with brain-related traits, identification of the variants, genes and molecular …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
Landscape of conditional eQTL in dorsolateral prefrontal cortex and co-localization with schizophrenia GWAS
Causal genes and variants within genome-wide association study (GWAS) loci can be
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
There is increasing evidence that many risk loci found using genome-wide association
studies are molecular quantitative trait loci (QTLs). Here we introduce a new set of functional …
studies are molecular quantitative trait loci (QTLs). Here we introduce a new set of functional …
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Genome-wide association studies (GWASs) have identified many variants associated with
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues
Genetic association mapping produces statistical links between phenotypes and genomic
regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) …
regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) …
A meta-analysis of gene expression quantitative trait loci in brain
Current catalogs of brain expression quantitative trait loci (eQTL) are incomplete and the
findings do not replicate well across studies. All existing cortical eQTL studies are small and …
findings do not replicate well across studies. All existing cortical eQTL studies are small and …
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …
variants contribute to gene expression, have been performed in heterogeneous brain …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Estimating the causal tissues for complex traits and diseases
How to interpret the biological causes underlying the predisposing markers identified
through genome-wide association studies (GWAS) remains an open question. One direct …
through genome-wide association studies (GWAS) remains an open question. One direct …