Objective To understand changes in gene expression levels that occur during osteoarthritic
(OA) cartilage degeneration, using complementary DNA (cDNA)–array technology. Methods …

OBJECTIVES Matrix metalloproteinases (MMPs) are thought to be major mediators of
cartilage destruction. Osteoarthritis (OA) is characterised by cartilage degradation. This …

Objective To analyze the differences in gene expression profiles of chondrocytes in intact
and damaged regions of cartilage from the same knee joint of patients with osteoarthritis …

Objective To determine the chondrocyte metabolism in respective zones of osteoarthritic
(OA) cartilage. Methods OA cartilage was obtained from macroscopically intact areas of 4 …

Objective Despite many research efforts in recent decades, the major pathogenetic
mechanisms of osteoarthritis (OA), including gene alterations occurring during OA cartilage …

OBJECTIVE: To elucidate disease-specific molecular changes in osteoarthritis (OA) by
analyzing the differential gene expression profile of damaged vs intact cartilage areas within …

Objective Osteoarthritic (OA) cartilage destruction depends on collagenand aggrecan
degrading proteases such as collagenases (MMP1 and MMP13), stromelysin (MMP3) …

INTRODUCTION: Although the extracellular matrix (ECM) is the functional element in
articular cartilage and its degradation is central in the pathogenetic process in osteoarthritis …

The biochemical properties of articular cartilage rely on the biochemical composition and
integrity of its extracellular matrix. This matrix consists mainly of a collagen network and the …

The molecular basis to mammalian osteoarthritis (OA) is unknown. We hypothesised that the
expression of selected proteases, matrix molecules, and collagens believed to have a role in …