The increased expression and/or abnormal processing of the amyloid precursor protein
(APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract βAmyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common
type of dementia in the elderly. One of the hallmarks of this disease is a progressive …

An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

Because of the central place of amyloid in the histopathology of Alzheimer's disease (AD*),
current research seeks to determine the proteolytic mechanisms involved in the processing …

Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the
focus of numerous investigations in the past two decades, since the identification of Aβ as …

The proteolytic cleavage of the amyloid precursor protein (APP) has been shown to be
modulated through specific muscarinic receptor activation in vitro in both transfected cell …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …