Background Mixed results in the predictive ability of traditional biomarkers to determine
cognitive functioning and changes in older adults have led to misdiagnosis and …

Conventional neuropsychological assessments for Alzheimer's disease are burdensome
and inaccurate at detecting mild cognitive impairment and predicting Alzheimer's disease …

Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for
current clinical practice. Promisingly, current tools can be complemented by computational …

Research into cognitive resilience imaging markers may help determine the clinical
significance of Alzheimer's disease pathology among older adults over 80 years (80+). In …

Abstract Background Recent Alzheimer's disease (AD) trials have faced significant
challenges to enroll pre-symptomatic or early stage AD subjects with biomarker positivity …

Background: It is difficult to assess brain health status and risk of cognitive impairment,
particularly at the initial evaluation. To address this, we developed the Brain Health Platform …

Background and Objectives Prior work suggests that cognitive resilience may contribute to
the heterogeneity of cognitive decline. This study examined whether distinct cortical proteins …

Objective: Risk factors that contribute to brain pathology and cognitive decline among older
adults include demographic factors (eg, age, educational attainment), genetic factors, health …

Objective: To define resilience metrics for cognitive decline based on plasma and
cerebrospinal fluid (CSF) amyloid-β (Aβ) and examine the demographic, genetic, and …

June 2019• Vol. 9 No. 1• 010317 2 www. jogh. org• doi: 10.7189/jogh. 09.010317 but the
most recent criteria (ref. s12 in Online Supplementary Document) draw the strongest …