Intraprocedural MRI-based dosimetry during transarterial radioembolization of liver tumours with holmium-166 microspheres (EMERITUS-1): a phase I trial towards …

J Roosen, LEL Westlund Gotby, MJ Arntz… - European Journal of …, 2022 - Springer
Purpose Transarterial radioembolization (TARE) is a treatment for liver tumours based on
injection of radioactive microspheres in the hepatic arterial system. It is crucial to achieve a …

Improving MRIbased dosimetry for holmium166 transarterial radioembolization using a nonrigid image registration for voxelwise Δ R 2∗ ΔR_2^* calculation

J Roosen, MWM van Wijk, LEL Westlund Gotby… - Medical …, 2023 - Wiley Online Library
Background Transarterial radioembolization (TARE) is a treatment modality for liver tumors
during which radioactive microspheres are injected into the hepatic arterial system. These …

Development of an MRI-guided approach to selective internal radiation therapy using holmium-166 microspheres

J Roosen, MJ Arntz, MJR Janssen, SF de Jong… - Cancers, 2021 - mdpi.com
Simple Summary Selective internal radiation therapy (SIRT) is a treatment for patients with
liver cancer that involves the injection of radioactive microspheres into the liver artery. For a …

Surefire infusion system versus standard microcatheter use during holmium-166 radioembolization: study protocol for a randomized controlled trial

AF van den Hoven, JF Prince, RCG Bruijnen… - Trials, 2016 - Springer
Background An anti-reflux catheter (ARC) may increase the tumor absorbed dose during
radioembolization (RE) by elimination of particle reflux and its effects on hemodynamics …

High quality imaging and dosimetry for yttrium-90 (90Y) liver radioembolization using a SiPM-based PET/CT scanner

H Duan, MH Khalaf, V Ferri, L Baratto… - European Journal of …, 2021 - Springer
Purpose Transarterial radioembolization (TARE) with yttrium-90 (90 Y) microspheres is a
liver-directed treatment for primary and secondary hepatic malignancies. Personalized …

Efficacy of radioembolization with 166Ho-microspheres in salvage patients with liver metastases: a phase 2 study

JF Prince, MAAJ van den Bosch… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Radioembolization of liver malignancies with 166Ho-microspheres has been shown to be
safe in a phase 1 dose-escalation study. The purpose of this study was to investigate the …

Microsphere localization and dose quantification using positron emission tomography/CT following hepatic intraarterial radioembolization with yttrium-90 in patients …

WB Lea, KN Tapp, M Tann, GD Hutchins… - Journal of Vascular and …, 2014 - Elsevier
Purpose To characterize the distribution of absorbed radiation dose after glass microsphere
radioembolization for hepatocellular carcinoma (HCC) using yttrium-90 (90 Y) positron …

MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors

C Huesa-Berral, JD Withrow, RJ Dawson… - European Journal of …, 2024 - Springer
Purpose Transarterial radioembolization (TARE) procedures treat liver tumors by injecting
radioactive microspheres into the hepatic artery. Currently, there is a critical need to optimize …

[HTML][HTML] Clinical application of radioembolization in hepatic malignancies: protocol for a prospective multicenter observational study

T Helmberger, D Arnold, JI Bilbao… - JMIR Research …, 2020 - researchprotocols.org
Background: Radioembolization, also known as transarterial radioembolization or selective
internal radiation therapy with yttrium-90 (90Y) resin microspheres, is an established …

Holmium-166 radioembolisation in patients with unresectable, chemorefractory liver metastases (HEPAR trial): a phase 1, dose-escalation study

MLJ Smits, JFW Nijsen, MAAJ van den Bosch… - The lancet …, 2012 - thelancet.com
Background The efficacy of radioembolisation for the treatment of liver tumours depends on
the selective distribution of radioactive microspheres to tumorous tissue. The distribution of …