Mesenchymal stem cells (MSCs) are defined by their ability to selfrenew and differentiate
into the cells that form mesodermal tissues such as bone and fat. Low magnitude …

This study examined the effects of mechanical strain on osteogenic and adipogenic
differentiation of cultured MSCs by stimulating MSCs cultured in general and adipogenic …

Mechanical signals of both low and high intensity are inhibitory to fat and anabolic to bone in
vivo, and have been shown to directly affect mesenchymal stem cell pools from which fat …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

The ability of exercise to decrease fat mass and increase bone mass may occur through
mechanical biasing of mesenchymal stem cells (MSCs) away from adipogenesis and toward …

Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease
muscle mass and strength, and undermine postural stability, culminating in an elevated risk …

Deterioration of the immune and skeletal systems, each of which parallel obesity, reflects a
fragile interrelationship between adiposity and osteoimmunology. Using a murine model of …

Background Reduced bone formation is associated with increased bone marrow fat in many
bone-loss related diseases including aging, post-menopause, and anorexia nervosa …

Obesity represents a risk factor for development of insulin resistance and type 2 diabetes. In
addition, it has been associated with increased adipocyte formation in the bone marrow …

In the adult bone marrow, osteoblasts and adipocytes share a common precursor called
mesenchymal stem cells (MSCs). The plasticity between the two lineages has been …