Recent genetic findings in schizophrenia and their therapeutic relevance

PJ Harrison - Journal of psychopharmacology, 2015 - journals.sagepub.com
Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …

BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …

Molecular genetics of schizophrenia: a critical review

N Berry, V Jobanputra, H Pal - Journal of Psychiatry and Neuroscience, 2003 - jpn.ca
We present an overview of current progress and future directions in the molecular genetics
of schizophrenia. We review linkage studies, involving the genome-wide scan of …

[HTML][HTML] Genetics of schizophrenia: overview of methods, findings and limitations

MG Henriksen, J Nordgaard… - Frontiers in human …, 2017 - frontiersin.org
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

Genetics of schizophrenia

I Escudero, M Johnstone - Current psychiatry reports, 2014 - Springer
The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Proceedings of the Australian neuroscience society symposium: Schizophrenia molecular genetics of schizophrenia

BJ Mowry, DJ Nancarrow - Clinical and Experimental …, 2001 - Wiley Online Library
Schizophrenia is a chronic, disabling brain disease that affects approximately 1% of the
world's population. It is characterized by delusions, hallucinations and formal thought …

Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research

MJ Arranz, J De Leon - Molecular psychiatry, 2007 - nature.com
The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …

Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics

I Giegling, L Hosak, R Mössner, A Serretti… - The world journal of …, 2017 - Taylor & Francis
Objectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general
population. The relative contribution of genetic factors has been estimated to be up to 80 …

Schizophrenia genetics: emerging themes for a complex disorder

DH Kavanagh, KE Tansey, MC O'Donovan… - Molecular …, 2015 - nature.com
After two decades of frustration, genetic studies of schizophrenia have entered an era of
spectacular success. Advances in genotyping technologies and high throughput …

[HTML][HTML] Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …