Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …

Like bone mass, bone quality is specified in development, actively maintained postnatally,
and disrupted by disease. The roles of osteoblasts, osteoclasts, and osteocytes in the …

Genetic diseases and knockout mice stress the importance of matrix metalloproteinases
(MMPs) in skeletal turnover. Our study aims at clarifying which MMPs are expressed by …

Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

The matrix metalloproteinase (MMP) family of extracellular proteases performs crucial roles
in development and repair of the skeleton owing to their ability to remodel the extracellular …

Matrix metalloproteinases (MMPs) are degrading enzymes that have a pivotal function in
extracellular matrix remodeling. More than half of the MMP members are expressed by bone …

Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix
(ECM), as well as many nonECM molecules. MMPs participate in (1) degradation of ECM to …

Matrix metalloproteinases (MMPs) are capable of processing certain components of bone
tissue, including type 1 collagen, a determinant of the biomechanical properties of bone …

The 'vanishing bone'or inherited osteolysis/arthritis syndromes represent a heterogeneous
group of skeletal disorders characterized by mineralization defects of affected bones and …

The assembly and degradation of extracellular matrix (ECM) molecules are crucial
processes during bone development. In this study, we show that ECM remodeling is a …