Coolant-assisted liquid nitrogen (LN) flash freezing of frozen tissues has been widely
adopted to preserve tissue morphology for histopathological annotations in mass …

Preservation of ultrastructural features in biological samples for electron microscopy (EM) is
a challenging task that is routinely accomplished through chemical fixation or high-pressure …

Preservation of tissue structure, morphology and biomarkers is of utmost importance for
pathological examination of biopsy specimens for diagnostic and therapeutic purposes …

At the heart of the phenome-to-genome approach is high throughput assays, which are
liable to produce false results. This risk can be mitigated by minimizing the sample bias …

Background The development of nanoscale secondary ion mass spectrometry (NanoSIMS)
has revolutionized the study of biological tissues by enabling, eg, the visualization and …

There is growing interest in proteomic analyses of tissue biopsies to reveal pathophysiology
and identify biomarkers. The current gold standard for collecting tissue biopsies for …

Background: The freezing process of tissue samples is crucial for the preservation of
morphological and molecular features. Several biobanking guidelines describe freezing …

Electron microscopy (EM) offers unparalleled power to study cell substructures at the
nanoscale. Cryofixation by high-pressure freezing offers optimal morphological …

Cryopreservation is routine in biomedical research and clinical practice for various
purposes, including sample transportation, RNA preservation, and long-term storage …

Protein degradation that occurs in tissue during postmortem interval or sample preparation
is problematic in quantitative analyses as confounding variables may arise. Ideally, such …