It has been previously suggested that morphine can regulate the expression and function of
some proteins of the cytoskeleton. In the present study, we used real-time quantitative …

Drug withdrawal is associated with abstinence symptoms including deficits in cognitive
functions that may persist even after prolonged discontinuation of drug intake. Cognitive …

Background Immediate early gene (IEG) induction elicited by drugs of abuse may contribute
to development of plastic changes in the brain responsible for drug-induced behavioral …

Opioid addiction is recognized as a chronic relapsing brain disease resulting from repeated
exposure to opioid drugs. Cellular and molecular mechanisms underlying the ability of …

Repeated administration of morphine induced a timedependent inhibition of the morphine
induced antinociceptive action, indicating the development of tolerance to morphine. We …

Altered synaptic transmission and plasticity in brain areas involved in reward and learning
are thought to underlie the longlasting effects of addictive drugs. In support of this idea …

The long-term response to neurotropic drugs depends on drug-induced neuroplasticity and
underlying changes in gene expression. However, alterations in neuronal gene expression …

Using primary neuronal cell culture assays, combined with 2D gel electrophoresis and
capillary LC–MS, we identified differences in proteomes between control and morphine …

Morphine has been used as a potent analgesic, having a high propensity to induce
tolerance and physical dependence following their repeated administration. Although the …

Repeated exposure to drugs of abuse causes timedependent neuroadaptive changes in
the mesocorticolimbic system of the brain that are considered to underlie the expression of …