Location is important: differentiation between ileal and colonic Crohn's disease

R Atreya, B Siegmund - Nature Reviews Gastroenterology & …, 2021 - nature.com
Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

Should we divide Crohn's disease into ileum-dominant and isolated colonic diseases?

PS Dulai, S Singh, NV Casteele, BS Boland… - Clinical …, 2019 - Elsevier
Crohn's disease (CD) is an inflammatory bowel disease that can involve any region of the
gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it …

Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?

S Subramanian, A Ekbom, JM Rhodes - Gut, 2017 - gut.bmj.com
The genetics of isolated colonic Crohn's disease place it approximately midway between
Crohn's disease with small intestinal involvement and UC, making a case for considering it …

Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis

RB Sartor - Nature clinical practice Gastroenterology & hepatology, 2006 - nature.com
Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory
conditions that are immunologically mediated. Although their exact etiologies remain …

Crohn's disease: a clinical update

F Ha, H Khalil - Therapeutic advances in gastroenterology, 2015 - journals.sagepub.com
Crohn's disease is increasing in prevalence worldwide. It arises from a complex interplay
between both genetic predisposition and environmental influence. A search of databases …

A comprehensive review and update on Crohn's disease

M Gajendran, P Loganathan, AP Catinella… - Disease-a-month, 2018 - Elsevier
The term inflammatory bowel disease (IBD) refers principally to two major categories of
chronic relapsing inflammatory intestinal disorders: Crohn's disease (CD) and ulcerative …

Crohn's disease

G Roda, S Chien Ng, PG Kotze, M Argollo… - Nature Reviews …, 2020 - nature.com
Crohn's disease is an inflammatory bowel disease that is characterized by chronic
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …

Natural history and clinical behavior of Crohn's disease extending beyond two decades

HJ Freeman - Journal of clinical gastroenterology, 2003 - journals.lww.com
Crohn's disease is a heterogeneous inflammatory disorder characterized by strictures or
perforating complications. Information on natural history is limited. In the present study, 150 …

Molecular classification of Crohn's disease reveals two clinically relevant subtypes

M Weiser, JM Simon, B Kochar, A Tovar, JW Israel… - Gut, 2018 - gut.bmj.com
Objective The clinical presentation and course of Crohn's disease (CD) is highly variable.
We sought to better understand the cellular and molecular mechanisms that guide this …

A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998

C Gasche, J Scholmerich, J Brynskov… - Inflammatory bowel …, 2000 - Wiley Online Library
Crohn's disease is a heterogeneous entity. Previous attempts of classification have been
based primarily on anatomic location and behavior of disease. However, no uniform …