A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to
distribute in the brain by a receptor-mediated process. With single-photon-emission imaging …

A simple quantitative autoradiographic technique for the study of neurotransmitter receptors
that includes the use of a tritium-sensitive film permits saturation, kinetic, and competition …

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated
from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian …

The relative distribution of muscarinic and nicotinic cholinergic receptors labeled with [3 H]
acetylcholine was determined using autoradiography.[3 H] acetylcholine binding to high …

THE presence of cholinergic muscarinic receptors on neurones in many regions of the
mammalian brain is known from classical electrophysiological studies, which showed that …

The distribution of muscarinic cholinergic receptors in the human forebrain and cerebellum
was studied in detail by quantitative autoradiography using N-[3H] methylscopolamine as a …

Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic
cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by …

Injection of a potent, cholinergic muscarinic antagonist,[3 H] 3-quinuclidinyl benzilate ([3 H]
QNB), results in a localization of the drug to muscarinic receptors in rat brain. The …

Interaction of Acetylcholine with Different Cholinergic Page 1 36 NATURE VOL. 225 JANUARY
3 1 97O Interaction of Acetylcholine with Different Cholinergic Nerve Receptors by GGLaL S …

Prior studies have suggested the presence of muscarinic acetylcholine receptor (MAChR)
subtypes within the mammalian central nervous system on the bases of functional ligand …