Brugada syndrome as a major cause of sudden cardiac death in Asians

Y Nakano, W Shimizu - JACC: Asia, 2022 - jacc.org
Brugada syndrome (BrS) is one of the main inherited arrhythmia syndromes causing
ventricular fibrillation (VF) and sudden cardiac death in young to middle-aged men …

Brugada syndrome genetics is associated with phenotype severity

G Ciconte, MM Monasky, V Santinelli… - European heart …, 2021 - academic.oup.com
Abstract Aims Brugada syndrome (BrS) is associated with an increased risk of sudden
cardiac death due to ventricular tachycardia/fibrillation (VT/VF) in young, otherwise healthy …

SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and metaanalysis

P Rattanawong, J Chenbhanich… - Annals of …, 2019 - Wiley Online Library
Abstract Background Brugada syndrome (BrS) is an inherited arrhythmic disease linked to
SCN5A mutations. It is controversial whether SCN5A mutation carriers possess a greater …

Genetics can contribute to the prognosis of Brugada syndrome: a pilot model for risk stratification

E Sommariva, C Pappone… - European Journal of …, 2013 - nature.com
Brugada syndrome is an inherited arrhythmogenic disorder leading to sudden death
predominantly in the 3–4 decade. To date the only reliable treatment is the implantation of a …

Assessment of markers for identifying patients at risk for lifethreatening arrhythmic events in Brugada syndrome

Y Ajiro, N Hagiwara, H Kasanuki - Journal of cardiovascular …, 2005 - Wiley Online Library
Introduction: Risk stratification for lifethreatening arrhythmic events in Brugada syndrome is
not yet established. The aim of the present study was to examine the usefulness of various …

Lack of genotype-phenotype correlation in Brugada syndrome and sudden arrhythmic death syndrome families with reported pathogenic SCN1B variants

B Gray, C Hasdemir, J Ingles, T Aiba, N Makita… - Heart Rhythm, 2018 - Elsevier
Background There is limited evidence that Brugada Syndrome (BrS) is due to SCN1B
variants (BrS5). This gene may be inappropriately included in routine genetic testing panels …

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

A Milman, A Andorin, PG Postema, JB Gourraud… - Heart Rhythm, 2019 - Elsevier
Background There is limited information on ethnic differences between patients with
Brugada syndrome (BrS) and arrhythmic events (AEs). Objective The purpose of this study …

Brugada syndrome: a fatal disease with complex genetic etiologies–still a long way to go

Y Wu, M Ai, ASA Bardeesi, L Xu, J Zheng… - Forensic sciences …, 2017 - academic.oup.com
Brugada syndrome (BrS) is an arrhythmogenic disorder which was first described in 1992.
This disease is a channelopathy characterized by ST-segment elevations in the right …

Brugada syndrome: clinical features, risk stratification, and management

BR Malik, AMA Rudwan, MS Abdelghani, M Mohsen… - Heart …, 2020 - journals.lww.com
In 1992, the Brugada brothers published a patient series of aborted sudden death, who were
successfully resuscitated from ventricular fibrillation (VF). These patients had a characteristic …

Testing the burden of rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome

S Le Scouarnec, M Karakachoff… - Human molecular …, 2015 - academic.oup.com
Abstract The Brugada syndrome (BrS) is a rare heritable cardiac arrhythmia disorder
associated with ventricular fibrillation and sudden cardiac death. Mutations in the SCN5A …