Drugs for the control of parasitic diseases: current status and development in schistosomiasis

A Fenwick, L Savioli, D Engels, NR Bergquist… - Trends in …, 2003 - cell.com
The morbidity caused by schistosomiasis has been controlled in China, Egypt and the
Philippines mainly by the widespread use of the safe and efficacious drug praziquantel …

Towards control of schistosomiasis in sub-Saharan Africa

VR Southgate, D Rollinson, LAT Tchuenté… - Journal of …, 2005 - cambridge.org
Approximately 80% of the 200 million people infected with schistosomiasis inhabit sub-
Saharan Africa, and the annual mortality is estimated to be 280,000. Praziquantel is the drug …

Implementation of human schistosomiasis control: challenges and prospects

A Fenwick, D Rollinson, V Southgate - Advances in parasitology, 2006 - Elsevier
Schistosomiasis is a major disease of public health importance in humans occurring in over
70 countries of the tropics and sub-tropics. In this chapter, the history of the control of …

Antischistosomal drugs: past, present… and future?

D Cioli, L Pica-Mattoccia, S Archer - Pharmacology & therapeutics, 1995 - Elsevier
The major antischistosomal drugs that have been or still are in use against infections with
schistosomes are considered here together with some compounds that have not been in …

Chemotherapy of schistosomiasis: an update

D Cioli - Parasitology Today, 1998 - cell.com
No major changes have occurred during the past 20 years regarding the therapeutic tools
available to the clinician for the treatment of schistosomiasis. If anything, the two drugs …

[PDF][PDF] Antischistosomal natural compounds: present challenges for new drug screens

J de Moraes - Current topics in tropical medicine, 2012 - repositorio.utp.edu.co
Schistosomiasis, or bilharzias, is a neglected disease that remains a considerable public
health problem in tropical and subtropical regions. This parasitic disease is the most …

Will new antischistosomal drugs finally emerge?

D Cioli, C Valle, F Angelucci, AE Miele - Trends in parasitology, 2008 - cell.com
It has been often observed that the chemotherapeutic armamentarium against an important
disease such as schistosomiasis consists of just one drug, praziquantel. Thus, development …

Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials

J Utzinger, J Keiser, X Shuhua, M Tanner… - Antimicrobial agents …, 2003 - Am Soc Microbiol
Schistosomiasis is a chronic and debilitating disease that is caused by parasitic trematode
worms (schistosomes). It continues to threaten millions of people, particularly the rural poor …

Research and development of antischistosomal drugs in the People's Republic of China: a 60-year review

SH Xiao, J Keiser, MG Chen, M Tanner… - Advances in …, 2010 - Elsevier
A comprehensive 60-year review of antischistosomal drug discovery and development
research in the People's Republic of China (PR China) is presented. In the 1950s, three …

Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

R Bergquist, J Utzinger, J Keiser - Infectious diseases of poverty, 2017 - Springer
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty
with considerable public health and socioeconomic impact, is based on preventive …