Hepatic stellate cells are similar to tissue pericytes and have been shown to be contractile.
In this study, we examined the effects of known mediators of stellate cell contraction on …

Hepatic stellate cells have received considerable attention as key components of the
fibrogenic response to injury. Beyond this feature, they also have been implicated as …

Portal hypertension is one of the most important cirrhosis-associated complications of
chronic liver disease, leading to significant morbidity and mortality. After chronic liver injury …

Hepatic stellate cells (Ito cells) are perisinusoidal cells with features typical of tissue
pericytes which have been implicated in the modulation of sinusoidal blood flow. They …

Recent evidence suggests that hepatic stellate cells function as liverspecific pericytes that
are highly contractile in response to endothelin1 (ET1). Liver injury has been shown to …

Although it has been hypothesized that contraction of hepatic stellate cells (HSC) regulates
blood flow by modulating sinusoidal resistance, neither HSC contraction nor relaxation has …

Although migration of stellate cells during hepatic injury is essential for wound-healing and
fibrosis of the liver, the extracellular and intracellular signals that regulate stellate cell …

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver
microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary …

Endothelin (ET) peptides have been implicated in the pathogenesis of several biological
processes within the liver. ET levels are elevated in the circulation of patients with cirrhosis …

The liver's response to chronic injury is fibrosis, which is analogous to wound healing in
other organs. Hepatic wounding is characterized by the" activation" of resident stellate cells …