During sepsis, the liver plays a key role. It is implicated in the host response, participating in
the clearance of the infectious agents/products. Sepsis also induces liver damage through …

Recent studies have revealed liver dysfunction as an early event in sepsis. Sepsis-
associated liver dysfunction is mainly resulted from systemic or microcirculatory …

Sepsis and septic shock are characterized by life-threatening organ dysfunction caused by a
dysregulated host response to infection. The liver has a central role during sepsis, and is …

Organ dysfunction or overt failure is a commonplace event in the critically ill affecting up to
70% of patients during their stay in the ICU. The outcome depends on the resolution of …

Despite continuous progress in medicine, sepsis remains the main cause of deaths in the
intensive care unit. Liver failure complicating sepsis/septic shock has a significant impact on …

Despite the progress made in the clinical management of sepsis, sepsis morbidity and
mortality rates remain high. The inflammatory pathogenesis and organ injury leading to …

Systemic inflammation contributes to significant morbidity in the ICU. With its ability to
generate antiinflammatory acute-phase proteins, cytokines via Kupffer cells, and recently …

AIM: To determine end-stage pathologic changes in the liver of septic patients dying in the
intensive care unit. METHODS: Needle liver biopsies obtained immediately after death from …

Introduction Liver dysfunction can derive from severe sepsis and might be associated with
poor prognosis. However, diagnosis of septic liver dysfunction is challenging due to a lack of …

Aim: Although it is a common complication of sepsis, sepsisassociated liver injury has not
been substantially recognized, because its diagnostic criteria and clinical implications are …