Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue …
M Chernoff, L Tong, K Demanelis… - Toxicological …, 2020 - academic.oup.com
Approximately 140 million people worldwide are exposed to inorganic arsenic through
contaminated drinking water. Chronic exposure increases risk for cancers as well as …
contaminated drinking water. Chronic exposure increases risk for cancers as well as …
[HTML][HTML] Inherited genetic effects on arsenic metabolism: A comparison of effects on arsenic species measured in urine and in blood
LI Tamayo, Y Kumarasinghe, L Tong… - Environmental …, 2022 - journals.lww.com
Inorganic arsenic (iAs) is a carcinogen, and chronic exposure is associated with adverse
health outcomes, including cancer and cardiovascular disease. Consumed iAs can undergo …
health outcomes, including cancer and cardiovascular disease. Consumed iAs can undergo …
[HTML][HTML] Sequencing-based fine-mapping and in silico functional characterization of the 10q24. 32 arsenic metabolism efficiency locus across multiple arsenic …
MB Chernoff, D Delgado, L Tong, L Chen, M Oliva… - PLoS …, 2023 - journals.plos.org
Inorganic arsenic is highly toxic and carcinogenic to humans. Exposed individuals vary in
their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is …
their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is …
Rare, Protein-Altering Variants in AS3MT and Arsenic Metabolism Efficiency: A Multi-Population Association Study
DA Delgado, M Chernoff, L Huang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Common genetic variation in the arsenic methyltransferase (AS3MT) gene
region is known to be associated with arsenic metabolism efficiency (AME), measured as the …
region is known to be associated with arsenic metabolism efficiency (AME), measured as the …
[HTML][HTML] Efficient Arsenic Metabolism — The AS3MT Haplotype Is Associated with DNA Methylation and Expression of Multiple Genes Around AS3MT
Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is
the efficiency of arsenic metabolism. The efficiency, in turn, is associated with non-coding …
the efficiency of arsenic metabolism. The efficiency, in turn, is associated with non-coding …
Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10
P GomezRubio, MM MezaMontenegro… - Journal of Applied …, 2010 - Wiley Online Library
Differences in arsenic metabolism are known to play a role in individual variability in arsenic
induced disease susceptibility. Genetic variants in genes relevant to arsenic metabolism are …
induced disease susceptibility. Genetic variants in genes relevant to arsenic metabolism are …
Polymorphisms in Arsenic(+III Oxidation State) Methyltransferase (AS3MT) Predict Gene Expression of AS3MT as Well as Arsenic Metabolism
K Engström, M Vahter, SJ Mlakar… - Environmental …, 2011 - ehp.niehs.nih.gov
Background Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid
(DMA) in humans, and the methylation pattern demonstrates large interindividual …
(DMA) in humans, and the methylation pattern demonstrates large interindividual …
High arsenic metabolic efficiency in AS3MT287Thr allele carriers
A Hernández, N Xamena, C Sekaran… - Pharmacogenetics …, 2008 - journals.lww.com
Objectives Epidemiological data indicate the existence of wide interindividual differences in
arsenic metabolism. It has recently been shown that arsenic (III) methyltransferase (AS3MT) …
arsenic metabolism. It has recently been shown that arsenic (III) methyltransferase (AS3MT) …
Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?
M Meza, AJ Gandolfi, WT Klimecki - Toxicology and applied pharmacology, 2007 - Elsevier
The complexity of arsenic toxicology has confounded the identification of specific pathways
of disease causation. One focal point of arsenic research is aimed at fully characterizing …
of disease causation. One focal point of arsenic research is aimed at fully characterizing …
[HTML][HTML] Individual Variations in Inorganic Arsenic Metabolism Associated with AS3MT Genetic Polymorphisms
T Agusa, J Fujihara, H Takeshita, H Iwata - International journal of …, 2011 - mdpi.com
Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic
(+ 3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl …
(+ 3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl …