Prescription opioid use disorder (POUD) has reached epidemic proportions in the United
States, raising an urgent need for diagnostic biological tools that can improve predictions of …

A dramatic increase in the use and dependence of prescription opioids has occurred within
the last 10 years. The consequences of long-term prescription opioid use and dependence …

Background Opioid use disorder is a chronic relapsing disorder. The brain adapts to opioids
that are taken for pain treatment or recreational use so that abstinence becomes a true …

Background Individual differences have been detected in individuals with opioid use
disorders (OUD) in rehabilitation following protracted abstinence. Recent studies suggested …

Opioid use disorder is a major public health crisis. While effective treatments are available,
outcomes vary widely across individuals and relapse rates remain high. Understanding …

Background: Increasing evidence suggests that heroin addiction may be related to the
dysfunction among the triple brain network (default mode network [DMN], salience network …

Individuals with opioid use disorder (OUD) have been reported to show abnormal brain
metabolism and impaired coupling among brain networks such as the default mode network …

Preclinical studies have shown effects of chronic exposure to addictive drugs on
glutamatergicmediated neuroplasticity in frontostriatal circuitry. These initial findings have …

It is widely accepted that addictive drug use is related to abnormal functional organization in
the user's brain. The present study aimed to identify this type of abnormality within the brain …

Previous neuroimaging studies have demonstrated both structural and functional damages
in heroin-dependent individuals. However, few studies investigated gray matter deficits and …