To characterize a glutamine synthetase (GS)-based selection system, monoclonal antibody
(mAb) producing recombinant CHO cell clones were generated by a single round of …

Chinese hamster ovary (CHO) cells are the biopharmaceutical industry's primary means of
manufacturing therapeutic proteins, including monoclonal antibodies. The major challenge …

Although Chinese hamster ovary (CHO) cells, with their unique characteristics, have
become a major workhorse for the manufacture of therapeutic recombinant proteins, one of …

A unique and nontraditional approach using glutamine and asparagine supplements for
CHOglutamine synthetase (GS) cell lines was studied. In our experiments, we found that a …

Therapeutic antibodies are commonly produced by high-expressing, clonal and
recombinant Chinese hamster ovary (CHO) cell lines. Currently, CHO cells dominate as a …

Chinese hamster ovary (CHO) cell cultivation for production of therapeutic proteins is
accompanied by production of metabolic wastes, mostly ammonia and lactate. To reduce …

Chinese hamster ovary (CHO) cells have been one of the most widely used host cells for the
manufacture of therapeutic recombinant proteins. An effective and efficient clinical cell line …

Conclusions GS technology has been successfully utilised for the expression of recombinant
antibodies. The vectors are capable of stable product accumulation over the extended …

To date, the FDA has approved 18 monoclonal antibody (MAb) therapeutic drugs with
targets ranging from asthma and rheumatoid arthritis to leukemia. Many of these approved …

Recombinant Chinese hamster ovary (CHO) cells expressing a humanized antibody were
obtained by transfection of an antibody expression vector (pKCGSHChuS) into CHOK1 …