Melatonin is the primary circadian output signal from the brain and is mainly synthesized in
pinealocytes. The rhythm and secretion of melatonin are under the control of an …

Because the chronobiotic and cytoprotective molecule melatonin diminishes with age, its
involvement in postmenopausal and senescence pathology has been considered since …

An important role for melatonin in bone formation and restructuring has emerged, and
studies demonstrate the multiple mechanisms for these beneficial actions. Statistical …

Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Melatonin may affect bone metabolism through bone anabolic as well as antiresorptive
effects. An age-related decrease in peak melatonin levels at nighttime is well documented …

Purpose Bone diseases account for an enormous cost burden on health systems. Bone
disorders are considered as age-dependent diseases. The aging of world population has …

Bone formation proceeds through a remodeling process that runs continuously, involving the
resorption of old bone by osteoclasts, and the subsequent formation of new bone by …

The purpose of this doubleblind study was to assess the effects of nightly melatonin
supplementation on bone health and quality of life in perimenopausal women. A total of 18 …

Melatonin is a bioamine produced primarily in the pineal gland, although peripheral sites,
including the gut, may also be its minor source. Melatonin regulates various functions …

In this study, the effects of the light/dark cycle, hormone replacement therapy (HRT), and
nocturnal melatonin supplementation on osteogenic markers and serum melatonin levels …