HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma

BJY Tan, K Sugata, O Reda, M Matsuo… - The Journal of …, 2021 - Am Soc Clin Investig
Human T cell leukemia virus type 1 (HTLV-1) mainly infects CD4+ T cells and induces
chronic, persistent infection in infected individuals, with some developing adult T cell …

HTLV-1-mediated epigenetic pathway to adult T-cell leukemia–lymphoma

M Yamagishi, D Fujikawa, T Watanabe… - Frontiers in …, 2018 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1), the first reported human oncogenic retrovirus,
is the etiologic agent of highly aggressive, currently incurable diseases such as adult T-cell …

HTLV-1 drives vigorous clonal expansion of infected CD8+ T cells in natural infection

A Melamed, DJ Laydon, H Al Khatib, AG Rowan… - Retrovirology, 2015 - Springer
Abstract Background Human T-lymphotropic Virus Type I (HTLV-1) is a retrovirus that
persistently infects 5–10 million individuals worldwide and causes disabling or fatal …

Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo

R Furuta, J Yasunaga, M Miura, K Sugata… - PLoS …, 2017 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) infects mainly CD4+ CCR4+ effector/memory T
cells in vivo. However, it remains unknown whether HTLV-1 preferentially infects these T …

[HTML][HTML] HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection

CRM Bangham, LB Cook, A Melamed - Seminars in cancer biology, 2014 - Elsevier
Human T lymphotropic virus type 1 (HTLV-1) causes a range of chronic inflammatory
diseases and an aggressive malignancy of T lymphocytes known as adult T-cell …

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

S Nakahata, D Enriquez-Vera, MI Jahan, K Sugata… - Biomolecules, 2023 - mdpi.com
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL).
HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host …

Human T-cell lymphotropic virus type 1 and its oncogenesis

L Zhang, J Wei, L Wang, S Huang… - Acta Pharmacologica …, 2017 - nature.com
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell
leukemia/lymphoma (ATL), a rapidly progressing clonal malignancy of CD4+ T lymphocytes …

Distinct transformation tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 is the result of postinfection T cell clonal expansion

P Kannian, H Yin, R Doueiri, MD Lairmore… - Journal of …, 2012 - Am Soc Microbiol
Human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 are related but pathogenically
distinct viruses. HTLV-1 mainly causes adult T cell leukemia, while HTLV-2 is not associated …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

N Araya, T Sato, H Ando, U Tomaru… - The Journal of …, 2014 - Am Soc Clin Investig
Human T-lymphotropic virus type 1 (HTLV-1) is linked to multiple diseases, including the
neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis …