Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology
Our capacity to measure diverse aspects of human biology has developed rapidly in the past
decades, but the rate at which these techniques have generated insights into the biological …
decades, but the rate at which these techniques have generated insights into the biological …
Phenomics: the systematic study of phenotypes on a genome-wide scale
Phenomics is an emerging transdiscipline dedicated to the systematic study of phenotypes
on a genome-wide scale. New methods for high-throughput genotyping have changed the …
on a genome-wide scale. New methods for high-throughput genotyping have changed the …
Unconsidered issues of measurement noninvariance in biological psychiatry: A focus on biological phenotypes of psychopathology
There is increasing appreciation that certain biological processes may not be equally related
to all psychiatric symptoms in a given diagnostic category. Research on the biological …
to all psychiatric symptoms in a given diagnostic category. Research on the biological …
Toward dynamic phenotypes and the scalable measurement of human behavior
Precision psychiatry demands the rapid, efficient, and temporally dense collection of large
scale and multi-omic data across diverse samples, for better diagnosis and treatment of …
scale and multi-omic data across diverse samples, for better diagnosis and treatment of …
Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?
Patients with mental disorders show many biological abnormalities which distinguish them
from normal volunteers; however, few of these have led to tests with clinical utility. Several …
from normal volunteers; however, few of these have led to tests with clinical utility. Several …
[HTML][HTML] Emerging methods and resources for biological interrogation of neuropsychiatric polygenic signal
E Uffelmann, D Posthuma - Biological Psychiatry, 2021 - Elsevier
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of
causal genetic variants that span much of the genome. This widespread polygenicity …
causal genetic variants that span much of the genome. This widespread polygenicity …
A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology
Neurogenetics research has begun to advance our understanding of how genetic variation
gives rise to individual differences in brain function, which, in turn, shapes behavior and risk …
gives rise to individual differences in brain function, which, in turn, shapes behavior and risk …
Why genetic investigation of psychiatric disorders is so difficult
Genetic investigations of psychiatric disease have historically relied on subjectively
assessed disease diagnoses to define phenotypes. Recent developments in several areas …
assessed disease diagnoses to define phenotypes. Recent developments in several areas …
Biological variables in psychopathology: A psychobiological perspective
DC Fowles - Comprehensive handbook of psychopathology, 1993 - Springer
In this chapter, we have reviewed the behavior genetic literature for a number of the major
forms of child and adult psychopathology, including schizophrenia, schizophrenia spectrum …
forms of child and adult psychopathology, including schizophrenia, schizophrenia spectrum …
Emerging phenotyping strategies will advance our understanding of psychiatric genetics
S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …
identified numerous significant loci. Whereas these studies initially depended on cohorts …