Drug abuse is a major problem worldwide. The incidence of drugrelated deaths attributed
to opiate abuse is increasing annually. Apart from routine examination, little is known of the …

The observation of increased hyperphosphorylated tau levels correlating with microglial
activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer …

Cognitive impairment is a recognized effect of drug misuse, including the use of opiates. The
pathological basis for this is unknown but the temporal and frontal cortices have been …

Psychosis occurs in 40–60% of Alzheimer's disease (AD) subjects, is heritable, and
indicates a more rapidly progressive disease phenotype. Neuroimaging and postmortem …

Animal studies demonstrate that hyperactive neurons facilitate early accumulation and
spread of tau and amyloid-β proteins in the pathological cascade of Alzheimer9s disease …

The distribution of abnormally phosphorylated tau proteins was investigated in a number of
cortical areas and in the basal nucleus of Meynert of 12 patients with Alzheimer's disease …

Aged individuals of mammalian species displaying hyperphosphorylated tau protein may be
suitable natural models for investigating neurodegenerative alterations occurring, for …

The objective of this study was to examine the distribution and severity of tau-PET binding in
cognitively normal adults with preclinical Alzheimer's disease as determined by positive beta …

The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages
ranging from 22 to 50 years upon death, were immunohistochemically assessed for …

The neuropathology associated with Alzheimer's disease (AD) is characterized by the
presence of extracellularly neuritic plaques, intracellularly neurofibrillary tangles and the …