Organic solvents offer a new approach to formulate DNA into novel structures suitable for
gene delivery. In this study, we examined the in situ behavior of DNA in N, N …

In the recent genomic era, a novel gene silencing approach has been introduced based on
the use of small synthetic oligonucleotides, such as antisense RNAs, siRNAs, to inhibit the …

The rapid developments of gene therapy are benefit from the construction of efficient gene
vectors, which help therapy genes efficiently overcome the barriers in the transport and …

Scanning force microscopy was used to examine DNA condensates prepared with varying
stoichiometries of lipospermine or polyethylenimine in physiological solution. For the first …

Cationic poly (aminoacids) like poly-l-lysine (PLL) are known to be efficient in condensing
plasmid DNA into compact nanostructures and have been used for in vitro and in vivo …

Cationic lipids and cationic polymers are widely used in gene delivery. Using 1, 2-dioleoyl-3-
trimethylammonium-propane (DOTAP) as a cationic lipid, we have investigated the stability …

The condensation of nucleic acids by lipids is a widespread phenomenon in biology with
crucial implications for drug delivery. However, the mechanisms of DNA assembly in lipid …

Here we explore the use of ethidium to determine relative affinities of different gene delivery
vectors for DNA and describe an improved method for studying the interaction. Specifically …

Giant DNA molecules of size greater than several kbp adopt an elongated coil conformation
in aqueous solution. On addition of various kinds of condensing agents, the giant DNA …

DMFs are spherical DNA–diacyllipid nanostructures formed by hydrophobic effects between
lipid tails coupled to single-stranded DNAs. Such properties as high cellular permeability …