Characterizing DNA condensation and conformational changes in organic solvents
F Ke, YK Luu, M Hadjiargyrou, D Liang - PLoS One, 2010 - journals.plos.org
Organic solvents offer a new approach to formulate DNA into novel structures suitable for
gene delivery. In this study, we examined the in situ behavior of DNA in N, N …
gene delivery. In this study, we examined the in situ behavior of DNA in N, N …
Interaction between 14mer DNA oligonucleotide and cationic surfactants of various chain lengths
In the recent genomic era, a novel gene silencing approach has been introduced based on
the use of small synthetic oligonucleotides, such as antisense RNAs, siRNAs, to inhibit the …
the use of small synthetic oligonucleotides, such as antisense RNAs, siRNAs, to inhibit the …
Interactions in DNA condensation: an important factor for improving the efficacy of gene transfection
The rapid developments of gene therapy are benefit from the construction of efficient gene
vectors, which help therapy genes efficiently overcome the barriers in the transport and …
vectors, which help therapy genes efficiently overcome the barriers in the transport and …
Nanoscopic structure of DNA condensed for gene delivery
DD Dunlap, A Maggi, MR Soria… - Nucleic acids …, 1997 - academic.oup.com
Scanning force microscopy was used to examine DNA condensates prepared with varying
stoichiometries of lipospermine or polyethylenimine in physiological solution. For the first …
stoichiometries of lipospermine or polyethylenimine in physiological solution. For the first …
DNA condensation by poly-L-lysine at the single molecule level: role of DNA concentration and polymer length
A Mann, R Richa, M Ganguli - Journal of Controlled Release, 2008 - Elsevier
Cationic poly (aminoacids) like poly-l-lysine (PLL) are known to be efficient in condensing
plasmid DNA into compact nanostructures and have been used for in vitro and in vivo …
plasmid DNA into compact nanostructures and have been used for in vitro and in vivo …
[HTML][HTML] Cationic lipids and cationic ligands induce DNA helix denaturation: detection of single stranded regions by KMnO4 probing
TK Prasad, V Gopal, NM Rao - FEBS letters, 2003 - Elsevier
Cationic lipids and cationic polymers are widely used in gene delivery. Using 1, 2-dioleoyl-3-
trimethylammonium-propane (DOTAP) as a cationic lipid, we have investigated the stability …
trimethylammonium-propane (DOTAP) as a cationic lipid, we have investigated the stability …
Mechanism of Cationic Lipid Induced DNA Condensation: Lipid–DNA Coordination and Divalent Cation Charge Fluctuations
W He, S Kirmizialtin - Biomacromolecules, 2024 - ACS Publications
The condensation of nucleic acids by lipids is a widespread phenomenon in biology with
crucial implications for drug delivery. However, the mechanisms of DNA assembly in lipid …
crucial implications for drug delivery. However, the mechanisms of DNA assembly in lipid …
Using ethidium to probe nonequilibrium states of DNA condensed for gene delivery
Here we explore the use of ethidium to determine relative affinities of different gene delivery
vectors for DNA and describe an improved method for studying the interaction. Specifically …
vectors for DNA and describe an improved method for studying the interaction. Specifically …
Controlling the higher-order structure of giant DNA molecules
K Yoshikawa - Advanced drug delivery reviews, 2001 - Elsevier
Giant DNA molecules of size greater than several kbp adopt an elongated coil conformation
in aqueous solution. On addition of various kinds of condensing agents, the giant DNA …
in aqueous solution. On addition of various kinds of condensing agents, the giant DNA …
DNA micelle flares: a study of the basic properties that contribute to enhanced stability and binding affinity in complex biological systems
DMFs are spherical DNA–diacyllipid nanostructures formed by hydrophobic effects between
lipid tails coupled to single-stranded DNAs. Such properties as high cellular permeability …
lipid tails coupled to single-stranded DNAs. Such properties as high cellular permeability …
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