[HTML][HTML] Exposure to violence accelerates epigenetic aging in children
Epigenetic processes, including DNA methylation, change reliably with age across the
lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic …
lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic …
[HTML][HTML] The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure
F Dammering, J Martins, K Dittrich, D Czamara… - Neurobiology of …, 2021 - Elsevier
Background Studies reporting accelerated ageing in children with affective disorders or
maltreatment exposure have relied on algorithms for estimating epigenetic age derived from …
maltreatment exposure have relied on algorithms for estimating epigenetic age derived from …
[HTML][HTML] DNA methylation profile is a quantitative measure of biological aging in children
X Wu, W Chen, F Lin, Q Huang, J Zhong, H Gao… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
DNA methylation changes within the genome can be used to predict human age. However,
the existing biological age prediction models based on DNA methylation are predominantly …
the existing biological age prediction models based on DNA methylation are predominantly …
Early adversities accelerate epigenetic aging into adulthood: a 10year, withinsubject analysis
WE Copeland, L Shanahan… - Journal of Child …, 2022 - Wiley Online Library
Background Longitudinal studies are needed to clarify whether early adversities are
associated with advanced methylation age or if they actually accelerate methylation aging …
associated with advanced methylation age or if they actually accelerate methylation aging …
Prenatal and early life influences on epigenetic age in children: a study of mother–offspring pairs from two cohort studies
DNA methylation-based biomarkers of aging are highly correlated with actual age.
Departures of methylation-estimated age from actual age can be used to define epigenetic …
Departures of methylation-estimated age from actual age can be used to define epigenetic …
The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort
Background: Statistical models that use an individual's DNA methylation levels to estimate
their age (known as epigenetic clocks) have recently been developed, with 96% correlation …
their age (known as epigenetic clocks) have recently been developed, with 96% correlation …
Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability
Childhood maltreatment is a key risk factor for poor mental and physical health. Recently,
variation in epigenetic processes, such as DNA methylation, has emerged as a potential …
variation in epigenetic processes, such as DNA methylation, has emerged as a potential …
Tracking the epigenetic clock across the human life course: a meta-analysis of longitudinal cohort data
Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …
Socioeconomic disadvantage and the pace of biological aging in children
METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …