Purpose We aimed to investigate associations between tau pathology and relative cerebral
blood flow (rCBF), and their relationship with cognition in Alzheimer's disease (AD), by using …

Abstract Purpose Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's
disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing …

Alzheimer's disease (AD) is associated with reduced temporo-parietal cerebral blood flow
(CBF). However, a substantial variability in CBF across the clinical spectrum of AD has been …

Background: The preclinical patterns of biological markers for Alzheimer's disease (AD) in
vivo need further exploration. The aim of this study was therefore to investigate CSF …

Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease
(AD), but vascular–tau associations and their effects on cognition are poorly understood. We …

Purpose Alpha-synuclein often co-occurs with Alzheimer's disease (AD) pathology in
Dementia with Lewy Bodies (DLB). From a dynamic [18 F] flortaucipir PET scan we derived …

Alzheimer's disease (AD) is a primary degenerative disease of the brain. The prevalence
increases with age, with devastating consequences for the individual and society. The aim of …

Objective To examine the cross-sectional associations between regional tau, β-amyloid
(Aβ), and cortical thickness and neuropsychological function across the preclinical and …

For amyloid positron emission tomography tracers, the simplified reference tissue model
derived ratio of influx rate in target relative to reference region (R1) has been shown to serve …

Amyloid-β pathology is associated with greater tau pathology and facilitates tau propagation
from the medial temporal lobe to the neocortex, where tau is closely associated with local …