Background: Low fibrinogen levels are known to occur in trauma. However, the extent of
fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and …

Fibrinogen plays an essential role in clot formation and stability. Importantly it seems to be
the most vulnerable coagulation factor, reaching critical levels earlier than the others during …

BACKGROUND: For critically injured patients requiring a massive transfusion, the optimal
plasma fibrinogen level is unknown. The purpose of this study was to examine the impact of …

BACKGROUND Despite poor evidence and high costs, fibrinogen concentrate (FC)
represents one of the most frequently used hemostatic agents in exsanguinating trauma …

Background Haemorrhage is a leading cause of death in severe trauma. Fibrinogen plays a
critical role in maintaining haemostasis in traumatic haemorrhage. Early fibrinogen …

Introduction Fibrinogen may be reduced following traumatic injury due to loss from
haemorrhage, increased consumption and reduced synthesis. In the absence of clinical …

Thromboelastography (TEG) is emerging as the standard in the management of acute
coagulopathies in injured patients. Although TEG is sensitive in detecting abnormalities in …

Background: To treat the coagulopathy of trauma, some have suggested early and
aggressive use of cryoprecipitate as a source of fibrinogen. Our objective was to determine …

Background. Decreased plasma fibrinogen concentration shortly after injury is associated
with higher blood transfusion needs and mortality. In North America and the UK …

Purpose Uncontrolled bleeding is the main preventable cause of death in severe trauma
patients. Fibrinogen is the first coagulation factor to decrease during trauma-induced …