The ability of naive T cells to clonally expand and acquire effector functions depends on the
strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory …

CD28 is the primary co-stimulatory receptor for inducing high-level IL-2 production and
survival of naïve CD4 (+) T cells. While no other cell surface receptor can be considered fully …

Previous work has shown that optimal activation of CD4+ T cells requires co-stimulatory
signals in addition to the primary signal provided by the antigen receptor. Recent work has …

JJ316 and JJ319 are rat CD28‐specific monoclonal antibodies (mAb) of the γ1χ isotype with
identical co‐stimulatory potency. At a concentration 100–1000‐fold higher than that required …

The efficiency and magnitude of T cell responses are influenced by ligation of the co‐
stimulatory receptor CD28 by B7 molecules expressed on antigen‐presenting cells (APC). In …

Antigen-specific T cell responses have primarily been considered in terms of activation
signals delivered through the TCR and the co-stimulatory molecule CD28. In the past few …

The CD28 homodimer is thought to function as a signal transducing receptor during
activation of T cells. Evidence is presented that the degree of aggregation of CD28 on the …

The crucial role for CD28, its homolog CTLA-4 and their binding partners B7-1 and B7-2 in
the generation of effective T-cell responses has been well documented. Recently, two new …

CD28 is a 44-kDa glycoprotein expressed as a homodimer on the surface of a major subset
of human T cells. Previous studies have demonstrated that the binding of monoclonal …

Ligation of CD28 provides a costimulatory signal to T cells necessary for their activation
resulting in increased interleukin (IL)‐2 production in vitro, but its role in IL‐4 and other …