With more than 4 million Alzheimer's victims nationwide, there is intense research to
elucidate the relationship among the hallmarks of the disease, amyloid plaques …

Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by
memory and cognitive loss, the formation of senile plaques containing amyloid-β (Aβ) …

It is generally accepted that the crucial events in the pathogeny of Alzheimer's disease (AD)
are the increased accumulation of amyloidogenic peptides derived from amyloid precursor …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

Alzheimer's disease is an age-related neurodegenerative disorder that is characterized by a
progressive loss of memory and deterioration of higher cognitive functions. The brain of an …

Amyloid imaging has identified cognitively normal older people with plaques as a group
possibly at increased risk for developing Alzheimer's disease-related dementia. It is …

Publisher Summary This chapter defines the interactions among beta amyloid (A β)
peptides, tau phosphorylation, and cholinergic neurons, and discusses the potential …

The mechanisms that contribute to selective vulnerability of the magnocellular basal
forebrain cholinergic neurons in neurodegenerative diseases, such as Alzheimer's disease …

The dysfunction and degeneration of cholinergic neuronal circuits in the brain is aprominent
feature of Alzheimers disease. Increasing data suggest that age-related oxidative …

Neurofibrillary lesions and senile plaques that are composed mainly of
hyperphosphorylated tau protein and the amyloid-β peptide derived from the amyloid …