No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples
Objective: Interest in candidate gene and candidate gene-by-environment interaction
hypotheses regarding major depressive disorder remains strong despite controversy …
hypotheses regarding major depressive disorder remains strong despite controversy …
The genetics of depression: a review
DF Levinson - Biological psychiatry, 2006 - Elsevier
Major depressive disorder (MDD) is common and moderately heritable. Recurrence and
early age at onset characterize cases with the greatest familial risk. Major depressive …
early age at onset characterize cases with the greatest familial risk. Major depressive …
Poor replication of candidate genes for major depressive disorder using genome-wide association data
FJ Bosker, CA Hartman, IM Nolte, BP Prins… - Molecular …, 2011 - nature.com
Abstract Data from the Genetic Association Information Network (GAIN) genome-wide
association study (GWAS) in major depressive disorder (MDD) were used to explore …
association study (GWAS) in major depressive disorder (MDD) were used to explore …
Genetic determinants of depression: recent findings and future directions
CME Harvard Review of Psychiatry offers CME for readers who complete questions about
featured articles. Questions can be accessed from the Harvard Review of Psychiatry website …
featured articles. Questions can be accessed from the Harvard Review of Psychiatry website …
Polygenic risk scores derived from varying definitions of depression and risk of depression
Importance Genetic studies with broad definitions of depression may not capture genetic risk
specific to major depressive disorder (MDD), raising questions about how depression …
specific to major depressive disorder (MDD), raising questions about how depression …
An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype
Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with …
studies that focused on either major depressive disorder or depressive symptoms with …
[HTML][HTML] Genetics of depression: progress at last
Abstract Purpose of Review We will describe the success of recent genome-wide
association studies that identify genetic variants associated with depression and outline the …
association studies that identify genetic variants associated with depression and outline the …
A genome-wide significant linkage for severe depression on chromosome 3: the depression network study
Objective: The purpose of this study was to find loci for major depression via linkage
analysis of a large sibling pair sample. Method: The authors conducted a genome-wide …
analysis of a large sibling pair sample. Method: The authors conducted a genome-wide …
[HTML][HTML] The implications of gene–environment interactions in depression: will cause inform cure?
R Uher - Molecular psychiatry, 2008 - nature.com
In a number of human diseases, including depression, interactions between genetic and
environmental factors have been identified in the absence of direct genotype-disorder …
environmental factors have been identified in the absence of direct genotype-disorder …
The current state of play on the molecular genetics of depression
S Cohen-Woods, IW Craig, P McGuffin - Psychological medicine, 2013 - cambridge.org
BackgroundIt has been well established that both genes and non-shared environment
contribute substantially to the underlying aetiology of major depressive disorder (MDD). A …
contribute substantially to the underlying aetiology of major depressive disorder (MDD). A …