Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

The state of our understanding of the interaction between pain and the brain is undergoing a
veritable revolution, with new surprising observations accumulating at a fast pace. A cursory …

Recent animal studies reveal ascending nociceptive and descending modulatory pathways
that may contribute to the affective–motivational aspects of pain and play a critical role in the …

Brain processing of pain in humans is based on multiple ascending pathways and brain
regions that are involved in several pain components, such as sensory, immediate affective …

Emotional–affective and cognitive dimensions of pain are less well understood than
nociceptive and nocifensive components, but the forebrain is believed to play an important …

This selective review discusses the psychobiological mediation of nociception and pain.
Summarizing literature from physiology and neuroscience, first an overview of the …

Clinical and experimental studies show serial interactions between the intensity of pain
sensation, pain unpleasantness, and secondary emotions associated with reflection and …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Attentional and emotional states alter the way we perceive pain. Recent findings suggest
that the mechanisms underlying these two forms of pain modulation are at least partially …

CONTEXT: The perception of pain due to an acute injury or in clinical pain states undergoes
substantial processing at supraspinal levels. Supraspinal, brain mechanisms are …